Both AA genotype of rs165599 and Val/Val genotype of rs4680 in COMT are associated with an increased risk of recurrence of prostate cancer

Introduction COMT expression was reported to be associated with the recurrence of prostate cancer. Furthermore, it has been shown that rs165599 SNP in 3’UTR affects interaction between miR-138 and COMT, while another polymorphism (rs4680) located gene also its expression. Here, we explored combined effect rs4680 . Material methods Kaplan-Meier analysis performed analyze PSA-progression-free survival cancer patients carrying different genotypes SNPs. IHC Western blot were used evaluate COMT. Real-time PCR carried out examine mRNA. Luciferase assay explore inhibitory role genotypes. Results The significantly increased rs165599-AA + rs4680-Val/Val genotype. In concordance this, remarkably elevated tissue samples collected from demonstrated COMT-G at effectively suppressed by through binding 3’ UTR COMT-G. notably precursors primary cells GG genotype rs165599. Conclusions findings this study carriers AA Val/Val showed an risk recurrence, these two polymorphisms may jointly function as a novel biomarker for prognosis recurrence.